General Specifications
Prometheus Panta
Prometheus NT.48
Prometheus NT.Plex
Prometheus NT.Plex + NT.Robotic Autosampler
Sample volume
10 µL
Sample handling format
Capillaries or capillary chip
Capillaries
Capillary chip
Capillary chip
Throughput in one run
Up to 48 capillaries or 24 in capillary chip
Up to 48 capillaries
24 in capillary chip
Up to 1536 in 64 capillary chips (before need to reload)
Temperature range
15 – 95 °C (up to 110 °C with High Temperature Upgrade)
15 – 95 °C
Heating rate range
Up to 95 °C: 0.1 – 7 °C/min
Above 95 °C: 0.1 – 7 °C/min
Up to 95 °C: 0.1 – 7 °C/min
Above 95 °C: 0.1 – 1 °C/min
Precision of 1 °C/min thermal ramp
± 0.2 °C
Optional upgrades
High temperature
High temperature, aggregation detection optics
High temperature, aggregation detection optics
Plate temperature control, aggregation detection optics
Optional automation
No
NT.Robotic Autosampler
N/A
21 CFR part 11 ready software
No
Yes
Dimensions
35 cm W x 51 cm H x 52 cm D
110 cm W x 188 cm H x 90 cm D
(stand-alone enclosure)
Weight
35 kg
30 kg
200 kg
Technical Specifications
Prometheus Panta
Prometheus NT.48
Prometheus NT.Plex
nanoDSF
Included
Measurement parameters
ratio: Tonset, Tm, Ea, reversibility of unfolding
330 nm: Tm
350 nm: Tm
ratio: Tonset, Tm, ΔG, ΔΔG, C50, Ea, isothermal stability, reversibility of unfolding
330 nm: Tm
350 nm: Tm
Concentration range
5 μg/mL – 250 mg/mL
Inflection point precision @ 75 °C
± 0.1 °C
Ratio precision/reproducibility
0.008
DLS
Included
N/A
Measurement parameters
Tscattering, Tsize, rH, PDI, kD, D0, average scattering intensity, reversibility of unfolding
N/A
Concentration range
0.5 mg/mL for a 15 kDa protein, up to 40% w/v
N/A
Size resolution
Down to 0.5 nm
N/A
Backreflection
Included
Optional upgrade
Measurement parameters
Tturbidity, reversibility of unfolding
Size resolution
Larger than 12.5 nm radius