Compare Prometheus Series

General Specifications	Prometheus Panta	Prometheus NT.48	Prometheus NT.Plex	Prometheus NT.Plex + NT.Robotic Autosampler
Sample volume	10 µL
Sample handling format	Capillaries or capillary chip	Capillaries	Capillaries or capillary chip	Capillaries or capillary chip
Throughput in one run	Up to 48 capillaries or 24 in capillary chip	Up to 48 capillaries	24 in capillary chip	Up to 1536 in 64 capillary chips (before need to reload)
Temperature range	15 – 95 °C (up to 110 °C with High Temperature Upgrade)			15 – 95 °C
Heating rate range	Up to 95 °C: 0.1 – 7 °C/min Above 95 °C: 0.1 – 7 °C/min	Up to 95 °C: 0.1 – 7 °C/min Above 95 °C: 0.1 – 1 °C/min
Precision of 1 °C/min thermal ramp	± 0.2 °C
Optional upgrades	High temperature	High temperature, aggregation detection optics	High temperature, aggregation detection optics	Plate temperature control, aggregation detection optics
Optional automation	No		NT.Robotic Autosampler	N/A
21 CFR part 11 ready software	No	Yes
Dimensions	35 cm W x 51 cm H x 52 cm D			110 cm W x 188 cm H x 90 cm D (stand-alone enclosure)
Weight	35 kg	30 kg		200 kg

Technical Specifications	Prometheus Panta	Prometheus NT.48	Prometheus NT.Plex
nanoDSF	Included
Measurement parameters	ratio: T_onset, T_m, E_a, reversibility of unfolding 330 nm: T_m 350 nm: T_m	ratio: T_onset, T_m, ΔG, ΔΔG, C₅₀, E_a, isothermal stability, reversibility of unfolding 330 nm: T_m 350 nm: T_m
Concentration range	5 μg/mL – 250 mg/mL
Inflection point precision @ 75 °C	± 0.1 °C
Ratio precision/reproducibility	0.008
DLS	Included	N/A
Measurement parameters	T_scattering, T_size, r_H, PDI, k_D, D₀, average scattering intensity, reversibility of unfolding	N/A
Concentration range	0.5 mg/mL for a 15 kDa protein, up to 40% w/v	N/A
Size resolution	Down to 0.5 nm	N/A
Backreflection	Included	Optional upgrade
Measurement parameters	T_turbidity, reversibility of unfolding
Size resolution	Larger than 12.5 nm radius

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